Điều trị thay thế nghiện các chất dạng thuốc phiện bằng Buprenorphine
(Baothanhhoa.vn) - Tại Thanh Hóa hiện đang có hơn 2.700 người điều trị nghiện các chất dạng thuốc phiện (CDTP) bằng Methadone, đây là biện pháp an toàn và hiệu quả cao. Tuy nhiên, việc bệnh nhân phải đến cơ sở y tế hàng ngày để uống cũng là một trở ngại trong duy trì điều trị nhất là với bệnh nhân các huyện miền núi hoặc vùng sâu, vùng xa. Sau một thời gian sử dụng Methadone đã bộc lộ một số hạn chế như: Tỷ lệ bỏ điều trị cao; tăng liều Methadone đối với bệnh nhân điều trị ARV do tương tác thuốc; bệnh nhân phải đến cơ sở uống thuốc hàng ngày làm ảnh hưởng đến công việc, thời gian và chi phí đi lại... Như vậy, bên cạnh Methadone thì Buprenorphine là một trong những giải pháp tối ưu để điều trị thay thế nghiện ma túy được Bộ Y tế chính thức đưa vào điều trị từ ngày 10-5-2019.
e525xfc4ax13ba8x14723x148b6xef9dxf2f4xf929x10ea2xX7x116cax11cffx16108x155f3xf974x14a83xX5x14cdbxXax11386x12d88xXdxe64dx12e43xX3xXex12361x122d6xX3xXexX1xX6x12c56xX3xXexX1x13319xX3x15512xf7aexX1xXdxf265xX25xX3xX4x10b9exX4xX3xX4xX1x14b78xXexX3x13bb2x114cdxX25xX26xX3xXexX1xX16x100aexX4xX3xXbxX1xXdxX29xX25xX3x10dd9x16066xX25xX26xX3x11967xX16xXbxX19xX10xX25x1693fxX19xXbxX1xXdxX25xX10xX0x13b68xX1xX2xX12xX0xXbxX3xX4xX5xX6xX7xX7xX9xXaxXbx11b8axX10xX6xX35xXaxX12xXcxX36xXdxX3xXcxX1xX6xX25xX1xX3xX68x165c9xX6xX3xX1xXdxX29xX25xX3x14cf6xX6xX25xX26xX3xX4xX79xX3xX1x1545dxX25xX3x14231xeb4ex12b21xe886xX90xX3xX25xX26x10591x1431fxXdxX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX25xX26xX1xXdxX29xX25xX3xX4xX2dxX4xX3xX4xX1xX32xXexX3xX35xX36xX25xX26xX3xXexX1xX16xX3dxX4xX3xXbxX1xXdxX29xX25xX3x14b25x1504ex14095xXcxff9cx11cf6xX3xX46xX47xX25xX26xX3x145e0xX10xXexX1xX6xX35xX51xX25xX10x12ef4xX3xX81x12868xX1fxX3xX5x12681xX3xX46xXdxX29xX25xX3xXbxX1xX2dxXbxX3xX6xX25xX3xXexX51xXdfxX25xX3x10739xXdfxX3xX1xXdxX29xX16xX3x10ee8xX16xf812xX3xX4xX6xX51xX8exX3xXcxX16xX1fxX3xX25xX1xXdxe6f7xX25xXd8xX3xXf3xXdxX29xX4xX3xX46xX29xX25xX1xX3xX25xX1xXdbxX25xX3xXbxX1xXfdxXdxX3xX81xX23xX25xX3xX4xX8axX3xX7xe53cxX3xX1fxX3xXexX23xX3xX1xXdfxX25xX26xX3xX25xX26xXdfxX1fxX3xX81x15ef9xX3xX16xX3dxX25xX26xX3xX4x160d6xX25xX26xX3xX5xXdfxX3x12903x15f1axXexX3xXexX19xX12bxX3xX25xX26xX36xXdxX3xXexX19xX51xX25xX26xX3xX35xX16xX1fxX3xXexX19xeb55xX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX25xX1xX32xXexX3xX5xXdfxX3xXf3x123a8xXdxX3xX46xX29xX25xX1xX3xX25xX1xXdbxX25xX3xX4xX2dxX4xX3xX1xX16xX1fxX29xX25xX3xX14cxXdxX15xX25xX3xX25x1482bxXdxX3xX1xX51xfb39xX4xX3xXf3x14e4dxX25xX26xX3xX7xXdbxX16xXd8xX3xXf3xX19fxX25xX26xX3x1637axX6xX8exX3x11e45xX6xX16xX3xX14cxX14dxXexX3xXexX1xX96xXdxX3xX26xXdxX6xX25xX3xX7x145e7xX3xX35x1174exX25xX26xX3xXcfxX10xXexX1xX6xX35xX51xX25xX10xX3xX81x14cddxX3xX46xX14dxX4xX3xX5xX14dxX3xX14cxX14dxXexX3xX7xX3dxX3xX1xX36xX25xX3xX4xX1xX23xX3xX25xX1xX95x13116xX3xXcxf036xX3xX5xX29xX3xX46x12e84xX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX4xX6xX51x10e4cxX3xXex10f1bxX25xX26xX3xX5xXdxX15xX16xX3xXcfxX10xXexX1xX6xX35xX51xX25xX10xX3xX81xX3dxXdxX3xXf3xX179xXdxX3xX46xX29xX25xX1xX3xX25xX1xXdbxX25xX3xX81xXdxX15xX16xX3xXexX19xX1axX3x13fc7x112c1x1087dxX3xX35xX51xX3xXexX95xX8axX25xX26xX3xXexX2dxX4xX3xXexX1xX16xX3dxX4xX208xX3xX46xX29xX25xX1xX3xX25xX1xXdbxX25xX3xXbxX1xXfdxXdxX3xX81xX23xX25xX3xX4xX8axX3xX7xX12bxX3xX16xX3dxX25xX26xX3xXexX1xX16xX3dxX4xX3xX1xXdfxX25xX26xX3xX25xX26xXdfxX1fxX3xX5xXdfxX14cxX3xXfdxX25xX1xX3xX1xX95xX12bxX25xX26xX3xX81xX23xX25xX3xX4x14f42xX25xX26xX3xXf3xXdxX29xX4xXd8xX3xXexX1xX96xXdxX3xX26xXdxX6xX25xX3xXf3xXdfxX3xX4xX1xXdxX3xXbxX1x1062exX3xX81xXdxX3xX5xX36xXdxX8exX8exX8exX3x15aefxX1xX95xX3xXf3x148a4xX1fxXd8xX3xX46xX10bxX25xX3xX4xX36xX25xX1xX3xXcfxX10xXexX1xX6xX35xX51xX25xX10xX3xXexX1xX165xX3xX4bxX16xXbxX19xX10xX25xX51xX19xXbxX1xXdxX25xX10xX3xX5xXdfxX3xX14cxX14dxXexX3xXexX19xX51xX25xX26xX3xX25xX1x134f6xX25xX26xX3xX26xXdxXfdxXdxX3xXbxX1xX2dxXbxX3xXexX3dxXdxX3xX95xX16xX3xX81xX13dxX3xX81xXdxX15xX16xX3xXexX19xX1axX3xXexX1xX6xX1fxX3xXexX1xX23xX3xX25xX26xX1xXdxX29xX25xX3xX14cxX6xX3xXexX196xX1fxX3xX81xX95x124dcxX4xX3xX4bxX14dxX3x11a7exX3xXexX23xX3xX4xX1xX2afxX25xX1xX3xXexX1x169aexX4xX3xX81xX95xX6xX3xXf3xXdfxX51xX3xX81xXdxX15xX16xX3xXexX19xX1axX3xXex11c78xX3xX25xX26xXdfxX1fxX3xX2xX90x11720xf191xX363xX8dxX90xX2x157f6xX8exX0xX59xXbxX12xX0xXbxX3xX4xX5xX6xX7xX7xX9xXaxXbxX4bxX51xX35xX1fxX3xXbxXc4xX10xX25xXexX10xX19xXaxX12xX0xXdxX14cxX26xX3xX4xX5xX6xX7xX7xX9xXaxXdxXc4xX10xX25xXexX10xX19xXaxX3xX7xXexX1fxX5xX10xX9xXax116faxXdxX35xXexX1xX1f1xX3x14eb5xX90xX90xXbxX1adxX208xX3xX1xX10xXdxX26xX1xXexX1f1xX3x14c27xX90xX3baxXbxX1adxX208xXaxX3xX7xX19xX4xX9xXaxX59xX59xXdxX8exX46xX6xX51xXexX1xX6xX25xX1xX1xX51xX6xX8exXf3xX25xX59xX25xX10xX3a4xX7xX59xX2xX369x14c68xX3abxX59xX2xX8fxX8fxX35xX3e1xX8dxX90xX8dxX3e1xX3baxX2xXexX3abxX2x1528cxX3f2xX8fxX5xX90xX8ex15b9exXbxX26x1163bxX19xX9xX8fxX364xX3abxXaxX3xX6xX5xXexX9xXaxX13xXdxX15xX16xX3xXexX19xX1axX3xXexX1xX6xX1fxX3xXexX1xX23xX3xX25xX26xX1xXdxX29xX25xX3xX4xX2dxX4xX3xX4xX1xX32xXexX3xX35xX36xX25xX26xX3xXexX1xX16xX3dxX4xX3xXbxX1xXdxX29xX25xX3xX46xX47xX25xX26xX3xX4bxX16xXbxX19xX10xX25xX51xX19xXbxX1xXdxX25xX10xXaxX3xX59xX12xX0xX59xXbxX12xX0xXbxX3xX4xX5xX6xX7xX7xX9xXaxXbxXc4xX6xXbxXexXdxX51xX25xXaxX12xXcxX95xX3xXf3xX32xX25xX3xXexX19xX95xX179xX4xX3xX81xXdxX15xX16xX3xXexX19xX1axX3xXexX1xX6xX1fxX3xXexX1xX23xX3xX25xX26xX1xXdxX29xX25xX3xX4xX2dxX4xX3xX4xX1xX32xXexX3xX35xX36xX25xX26xX3xXexX1xX16xX3dxX4xX3xXbxX1xXdxX29xX25xX3xX46xX47xX25xX26xX3xX4bxX16xXbxX19xX10xX25xX51xX19xXbxX1xXdxX25xX10xX3xX4xX1xX51xX3xX46xX29xX25xX1xX3xX25xX1xXdbxX25xX8exX3x15f58xX25xX1xX1f1xX3xX68xXdfxX3xX4bx146d1xX4xX0xX59xXbxX12xX0xXbxX3xX4xX5xX6xX7xX7xX9xXaxXbxX4bxX51xX35xX1fxXaxX12xX4bxX16xXbxX19xX10xX25xX51xX19xXbxX1xXdxX25xX10xX3xX25xX26xX51xXdfxXdxX3xX5xX332xXdxX3xX2afxX4xX1xX3xXexX95xX8axX25xX26xX3xXex165d9xX3xX25xX1xX95xX3xXcfxX10xXexX1xX6xX35xX51xX25xX10xX3xX5xXdfxX3xX26xXdxX196xXbxX3xX25xX26xX95xX96xXdxX3xX25xX26xX1xXdxX29xX25xX3xX4xX2dxX4xX3xXc4xXc5xXcxXc7xX3xX26xXdxXfdxX14cxX3xX5xX29xX3xXexX1xX16xX14dxX4xX3xXf3xXdfxX51xX3xX1xX10xX19xX51xXdxX25xX3xX1xX51xX19bxX4xX3xXexX1xX16xX3dxX4xX3xXbxX1xXdxX29xX25xXd8xX3xX26xXdxXfdxX14cxX3xX1xX14dxXdxX3xX4xX1xX345xX25xX26xX3xX4xX6xXdxX208xX3xXbxX1x15b63xX25xX26xX3xX81xX95xX332xX4xX3xX4xX2dxX4xX3xX46xX29xX25xX1xX3xX5xXdbxX1fxX3xXexX19xX16xX1fxX15xX25xX3xXfbxX16xX6xX3xX81xX95xX96xX25xX26xX3xX14cxX2dxX16xX3xX25xX1xX95xX3xX68x11315xX23bxXd8xX3xXf3xXdxX10bxX14cxX3xX26xX6xX25xX3xX4bxXd8xX3xXf3xXdxX10bxX14cxX3xX26xX6xX25xX3xXc4xX208xX3xX26xXdxXfdxX14cxX3xXexX1c4xX3xXf3xX51xX25xX26xX3xX35xX51xX3xX35xX19fxX25xX26xX3xXfbxX16xX2dxX3xX5xXdxX15xX16xX3xX1xX10xX19xX51xXdxX25xX208xX3xX26xXdxXfdxX14cxX3xX4xX2dxX4xX3xX1xXdfxX25xX1xX3xXf3xXdxX3xXbxX1xX36xX14cxX3xXbxX1xX2dxXbxX208xX3xX26xXdxX196xXbxX3xX25xX26xX95xX96xXdxX3xX25xX26xX1xXdxX29xX25xX3xXbxX1xX1c7xX4xX3xX1x1145cxXdxX3xX4xX1xX345xX4xX3xX25xX20bxX25xX26xX3xXexXdbxX14cxX3xX5x148e8xX3xX1adxX1d6xX3xX1xX14dxXdxXd8xX3xX5xX6xX51xX3xX81xX14dxX25xX26xX3xXf3xXdfxX3xX1xX57dxX6xX3xX25xX1xX2c0xXbxX3xX4xX14dxX25xX26xX3xX81xX623xX25xX26xX3xXexX1xX165xX3xX35xX51xX3xXexX1xX16xX3dxX4xX3xXexX2dxX4xX3xX35xX1c7xX25xX26xX3x136a4x13cc0xX51xX3xX35xXdfxXdxX3xX25xX10bxX25xX3xX674xX1xXdxX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX46xX47xX25xX26xX3xX4bxX16xXbxX19xX10xX25xX51xX19xXbxX1xXdxX25xX10xX3xX25xX26xX95xX96xXdxX3xX46xX29xX25xX1xX3xX4xX1xfbf7xX3xX4x13daexX25xX3xX8dxX3xX363xX3xX3e1xX3xX25xX26xXdfxX1fxX3xX14cxX179xXdxX3xXbxX1xXfdxXdxX3xX81xX23xX25xX3xX4xX8axX3xX7xX12bxX3xX1fxX3xXexX23xX3xX14cxX14dxXexX3xX5xX6b0xX25xX8exX3xXcxX35axX3xX81xX79xX3xX4xX145xX25xX26xX3xX26xXdxXfdxX14cxX3xX81xX2dxX25xX26xX3xX674xX13dxX3xXexX1xX96xXdxX3xX26xXdxX6xX25xX3xX81xXdxX3xX5xX36xXdxX3xX4xX1xX51xX3xX25xX26xX95xX96xXdxX3xX46xX29xX25xX1xX3xX25xX1xX32xXexX3xX5xXdfxX3xX25xX1xX2f8xX25xX26xX3xX46xX29xX25xX1xX3xX25xX1xXdbxX25xX3xX12bxX3xX1adxX6xX8exX3xXc5xX51xX3xX674xX1xX292xX25xX26xX3xX4xX79xX3xXexX95xX8axX25xX26xX3xXexX2dxX4xX3xXexX1xX16xX3dxX4xXd8xX3xX25xX10bxX25xX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX4bxX16xXbxX19xX10xX25xX51xX19xXbxX1xXdxX25xX10xX3xX12bxX3xX25xX26xX95xX96xXdxX3xX25xX26xX1xXdxX29xX25xX3xX14cxX6xX3xXexX196xX1fxX3xX25xX1xXdx1366axX14cxX3xX68xX5adxX23bxX3xX81xX6xX25xX26xX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX239xX23axX23bxX3xX4xX145xX25xX26xX3xX674xX1xX292xX25xX26xX3xX4xX6b0xX25xX3xXbxX1xXfdxXdxX3xXexX20bxX25xX26xX3xX5xXdxX15xX16xX3xXexX1xX16xX3dxX4xX3xX239xX23axX23bxX8exX0xX59xXbxX12xX0xXbxX3xX4xX5xX6xX7xX7xX9xXaxXbxX4bxX51xX35xX1fxXaxX12xXcxX36xXdxX3xXcxX1xX6xX25xX1xX3xX68xX79xX6xX3xX1xXdxX29xX25xX3xX81xX6xX25xX26xX3xXexX19xXdxX13dxX25xX3xX674xX1xX6xXdxX3xX4xX1xX95xX8axX25xX26xX3xXexX19xX165xX25xX1xX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX4bxX16xXbxX19xX10xX25xX51xX19xXbxX1xXdxX25xX10xX3xX4xX1xX51xX3xX46xX29xX25xX1xX3xX25xX1xXdbxX25xX3xXexX36xXdxX3xX3e1xX3xX4xX8axX3xX7xX12bxX3xX46xX6xX51xX3xX26xX623xX14cxX1f1xX3xXcxX19xX16xX25xX26xX3xXexXdbxX14cxX3xfbcdxXdxX13dxX14cxX3xX7xX51xX2dxXexX3xX46xX29xX25xX1xX3xXexX2c0xXexX3xXexX6adxX25xX1xX3xXcxX1xX6xX25xX1xX3xX68xX79xX6xX208xX3xXcxX19xX16xX25xX26xX3xXexXdbxX14cxX3xX338xX3xXexX23xX3xXcxXc7xX3xX1b1xX6b0xX14cxX3xX1b1xX8axX25xX208xX3xXcxX19xX16xX25xX26xX3xXexXdbxX14cxX3xX338xX3xXexX23xX3xX1xX16xX1fxX29xX25xX3xX2bbxX1xX95xX3xXcxX1xX6xX25xX1xX8exX3xX68xXdxX29xX25xX3xX4xX292xX25xX26xX3xXexX2dxX4xX3xX4xX1xX16x107b7xX25xX3xX46xX1axX3xX81xX1d6xX3xXf3xXdfxX3xX81xX6xX25xX26xX3xX674xX1xX8bfxX25xX3xXexX19xX95xX8axX25xX26xX3xX81xX95xX332xX4xX3xX1xX51xXdfxX25xX3xXexX32xXexX3xX81xX13dxX3xXexX1xX16xX3xX35xX16xX25xX26xX3xX46xX29xX25xX1xX3xX25xX1xXdbxX25xX3xXf3xXdfxX51xX3xX81xXdxX15xX16xX3xXexX19xX1axXd8xX3xX25xX1xX95xX1f1xX3xXcxX2c0xXbxX3xX1xX16xX32xX25xX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX4xX1xX51xX3xX4xX2dxX25xX3xX46xX14dxX3xX1fxX3xXexX23xX3xXexX36xXdxX3xX3e1xX3xX4xX8axX3xX7xX12bxX3xX81xXdxX15xX16xX3xXexX19xX1axX208xX3xX25xX1xX2c0xX25xX3xXexX1xX16xX3dxX4xX3xX4bxX16xXbxX19xX10xX25xX51xX19xXbxX1xXdxX25xX3xXexX35axX3xXc4xX1c7xX4xX3xXc7xX1xX57dxX25xX26xX3xX4xX1xX3dxX25xX26xX3xX68xX5adxX23bxX59xX239xX5adxXc5xX1b1xX3xXf3xX15xX3xX3e1xX3xX4xX8axX3xX7xX12bxX3xX81xXdxX15xX16xX3xXexX19xX1axX208xX3xXexXdxX23xXbxX3xX25xX1xX2c0xX25xX3xX1xX623xX3xX7xX8axX3xX46xX29xX25xX1xX3xX25xX1xXdbxX25xX3xX81xX20bxX25xX26xX3xX674xX635xX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX25xX26xX1xXdxX29xX25xX3xXc4xXc5xXcxXc7xX3xX46xX47xX25xX26xX3xX4bxX16xXbxX19xX10xX25xX51xX19xXbxX1xXdxX25xX10xX3xXexX36xXdxX3xX3e1xX3xX4xX8axX3xX7xX12bxX208xX3xX674xX1xX2dxX14cxX3xXexX95xX3xXf3xX32xX25xX3xXexX19xX95xX179xX4xX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX4xX1xX51xX3xX46xX29xX25xX1xX3xX25xX1xXdbxX25xX3xX81x1554dxX3xXexXdxX10bxX16xX3xX4xX1xX16xX8bfxX25xX3xX81xXdxX15xX16xX3xXexX19xX1axX8exX3xXcxX1xX96xXdxX3xX26xXdxX6xX25xX3xX674xX1xX12bxXdxX3xX5xXdxX15xX16xX3xXexX35axX3xX8dxX90xX363xX3f2xX363xX8dxX90xX2xX369xX3xXexX36xXdxX3xX2bbxX1xX95xX3xXcxX1xX6xX25xX1xXd8xX3xX7xX6xX16xX3xX81xX79xX3xXexX19xXdxX13dxX25xX3xX674xX1xX6xXdxX3xXexXdxX23xXbxX3xXexX36xXdxX3xX8dxX3xX4xX8axX3xX7xX12bxX3xX4xX57dxX25xX3xX5xX36xXdxX3xXexX19xX51xX25xX26xX3xXexX1xX2dxX25xX26xX3xX3f2xX363xX8dxX90xX2xX369xX8exX0xX59xXbxX12xX0xXbxX3xX4xX5xX6xX7xX7xX9xXaxXbxX4bxX51xX35xX1fxXaxX12xX13xX13dxX3xXexX19xXdxX13dxX25xX3xX674xX1xX6xXdxX3xX81xX95xX332xX4xX3xX1xX51xX36xXexX3xX81xX14dxX25xX26xX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX4xX1xX51xX3xX46xX29xX25xX1xX3xX25xX1xXdbxX25xX3xX25xX26xX1xXdxX29xX25xX3xX4xX2dxX4xX3xXc4xXc5xXcxXc7xX3xX4bxX16xXbxX19xX10xX25xX51xX19xXbxX1xXdxX25xX10xX3xXexX36xXdxX3xXcxX1xX6xX25xX1xX3xX68xX79xX6xXd8xX3xX4xX1xX95xX8axX25xX26xX3xXexX19xX165xX25xX1xX3xX81xX1d6xX3xX4xX79xX3xX7xX50exX3xXfbxX16xX6xX25xX3xXexXdbxX14cxX3xX81xX19bxX4xX3xX46xXdxX29xXexX3xX4xXa15xX6xX3xXc4xX1c7xX4xX3xXc7xX1xX57dxX25xX26xX3xX4xX1xX3dxX25xX26xX3xX68xX5adxX23bxX59xX239xX5adxXc5xX1b1xXd8xX3xXc5xX50exX3xX2dxX25xX3x13b13xX16x13d7bxX3xXcxX51xXdfxX25xX3xX4xX6b0xX16xX3xXbxX1xX57dxX25xX26xX3xX4xX1xX3dxX25xX26xX3xX68xX5adxX23bxX59xX239xX5adxXc5xX1b1xXd8xX3xX1b1xX12bxX3xX338xX3xXexX23xX3xXcxX1xX6xX25xX1xX3xX68xX79xX6xXd8xX8exX8exX8exX3xXexX19xX51xX25xX26xX3xX4xX292xX25xX26xX3xXexX2dxX4xX3xX4xX1xX6adxX3xX81xX36xX51xXd8xX3xX81xX623xX25xX26xX3xXexX1xX96xXdxX3xXexX36xX51xX3xX81xXdxX15xX16xX3xX674xXdxX29xX25xX3xXexX3dxXexX3xX25xX1xX32xXexX3xX4xX1xX51xX3xX25xX26xX95xX96xXdxX3xX25xX26xX1xXdxX29xX25xX3xX4xX2dxX4xX3xXc4xXc5xXcxXc7xX3xXexXdxX23xXbxX3xX4xX2c0xX25xX3xXf3xXdfxX3xX35xX16xX1fxX3xXexX19xX165xX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX4bxX16xXbxX19xX10xX25xX51xX19xXbxX1xXdxX25xX10xX3xX14cxX14dxXexX3xX4xX2dxX4xX1xX3xX5xXdbxX16xX3xX35xXdfxXdxX8exX0xX59xXbxX12xX0xXbxX3xX4xX5xX6xX7xX7xX9xXaxXbxX4bxX51xX35xX1fxXaxX12xXcxX1xX292xX25xX26xX3xXexXdxX25xX3xX4xX8axX3xX7xX12bxX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX25xX26xX1xXdxX29xX25xX3xX4xX2dxX4xX3xXc4xXc5xXcxXc7xX3xX46xX47xX25xX26xX3xX4bxX16xXbxX19xX10xX25xX51xX19xXbxX1xXdxX25xX10xX1f1xX0xX59xXbxX12xX0xX51xX5xX12xX0xX5xXdxX12xX0xXbxX3xX4xX5xX6xX7xX7xX9xXaxXbxX4bxX51xX35xX1fxXaxX12xXc7xX1xX57dxX25xX26xX3xX674xX1xX2dxX14cxX3xXf3xXdfxX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX68xX5adxX23bxX59xX239xX5adxXc5xX1b1xXd8xX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX25xX26xX1xXdxX29xX25xX3xX4xX1xX32xXexX3xXexX36xXdxX3xXcxX19xX16xX25xX26xX3xXexXdbxX14cxX3xX850xXdxX13dxX14cxX3xX7xX51xX2dxXexX3xX46xX29xX25xX1xX3xXexX2c0xXexX3xXexX6adxX25xX1xX3xXcxX1xX6xX25xX1xX3xX68xX79xX6xX3xXc3xX81xX1axX6xX3xX4xX1xX6adxX1f1xX3xXb5cxX16xX6xX25xX26xX3xXcxX19xX16xX25xX26xX3xX5adxX5adxX5adxXd8xX3xXbxX1xX95xX96xX25xX26xX3xX13xX292xX25xX26xX3xX23bxX29xXd8xX3xXcxXc7xX3xXcxX1xX6xX25xX1xX3xX68xX79xX6xXc8xX8exX0xX59xXbxX12xX0xX59xX5xXdxX12xX0xX5xXdxX12xX0xXbxX3xX4xX5xX6xX7xX7xX9xXaxXbxX4bxX51xX35xX1fxXaxX12xXcxX19xX16xX25xX26xX3xXexXdbxX14cxX3xX338xX3xXexX23xX3xXcxXc7xX3xX1b1xX6b0xX14cxX3xX1b1xX8axX25xX3xXc3xX81xX1axX6xX3xX4xX1xX6adxX1f1xX3xX13xX95xX96xX25xX26xX3xX2bbxX26xX16xX1fxX786xX25xX3xXc5xX16xXd8xX3xXbxX1xX95xX96xX25xX26xX3xX4bxX4d4xX4xX3xX1b1xX8axX25xXd8xX3xXcxXc7xX3xX1b1xX6b0xX14cxX3xX1b1xX8axX25xXc8xX8exX0xX59xXbxX12xX0xX59xX5xXdxX12xX0xX5xXdxX12xX0xXbxX3xX4xX5xX6xX7xX7xX9xXaxXbxX4bxX51xX35xX1fxXaxX12xXcxX19xX16xX25xX26xX3xXexXdbxX14cxX3xX338xX3xXexX23xX3xX1xX16xX1fxX29xX25xX3xX2bbxX1xX95xX3xXcxX1xX6xX25xX1xX3xXc3xX81xX1axX6xX3xX4xX1xX6adxX1f1xX3xXcxX1xX1axX3xXexX19xX32xX25xX3xX4bxX23xX25xX3xX1b1xX16xX25xX26xXd8xX3xX1xX16xX1fxX29xX25xX3xX2bbxX1xX95xX3xXcxX1xX6xX25xX1xXc8xX8exX0xX59xXbxX12xX0xX59xX5xXdxX12xX0xX59xX51xX5xX12xX0xXbxX3xX4xX5xX6xX7xX7xX9xXaxXbxX4bxX51xX35xX1fxXaxX3xX7xXexX1fxX5xX10xX9xXaxXexX10xX1adxXexX363xX6xX5xXdxX26xX25xX1f1xX3xX19xXdxX26xX1xXexX208xXaxX12xX0xX7xXexX19xX51xX25xX26xX12xX4bxX1b1xXc4xX850xX5adxX8exX3xX23bxX145xX3xX13xX165xX25xX1xX3xX2bbxX6xX14cxX0xX59xX7xXexX19xX51xX25xX26xX12xX0xX59xXbxX12xX0xXbxX3xX4xX5xX6xX7xX7xX9xXaxXbxX4bxX51xX35xX1fxXaxX3xX7xXexX1fxX5xX10xX9xXaxXexX10xX1adxXexX363xX6xX5xXdxX26xX25xX1f1xX3xX19xXdxX26xX1xXexX208xXaxX12xX0xX7xXexX19xX51xX25xX26xX12xXcxX19xX95xX12bxX25xX26xX3xXc7xX1xX57dxX25xX26xX3xX674xX1xX2dxX14cxX3xXf3xXdfxX3xX81xXdxX15xX16xX3xXexX19xX1axX3xX68xX5adxX23bxX59xX239xX5adxXc5xX1b1xXd8xX3xX0xX59xX7xXexX19xX51xX25xX26xX12xX0xX59xXbxX12xX0xXbxX3xX4xX5xX6xX7xX7xX9xXaxXbxX4bxX51xX35xX1fxXaxX3xX7xXexX1fxX5xX10xX9xXaxXexX10xX1adxXexX363xX6xX5xXdxX26xX25xX1f1xX3xX19xXdxX26xX1xXexX208xXaxX12xX0xX7xXexX19xX51xX25xX26xX12xX81xXdxX15xX16xX3xXexX19xX1axX3xX25xX26xX1xXdxX29xX25xX3xX4xX1xX32xXexX3xX363xX3xXcxX19xX16xX25xX26xX3xXexXdbxX14cxX3xX850xXdxX13dxX14cxX3xX7xX51xX2dxXexX3xX46xX29xX25xX1xX3xXexX2c0xXexX3xXexX6adxX25xX1xX3xXcxX1xX6xX25xX1xX3xX68xX79xX6xX0xX59xX7xXexX19xX51xX25xX26xX12xX0xX59xXbxX12